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Synthesis and Characterization of Arylspiroborates
Sedláčková, Simona ; Jelínek, Ivan (advisor) ; Sobotníková, Jana (referee)
Arylspiroborates have some very interesting properties, which include biological activities and the potential anti-tumor activities. The aim of the thesis was to prepare some complexes using mainly phenolic ligands (catchol, pyrogallol, 3-methoxycatechol, 2,3-dihydroxynaphthalene and 4tertButylcatechol) and their detailed characterization using ESI-QqTOF. With some of these prepared complexes collision experiments were performed and based on the results, the fragmentation mechanisms for these substances were proposed.
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Study of Boron-Carbohydrate Interaction
Vejvodová, Tereza ; Jelínek, Ivan (advisor) ; Coufal, Pavel (referee)
The interaction between boron and sugars is significant for understanding the role of boron as a carrier for nucleotides and carbohydrates. Arylboronic acids also have wide application as sugars sensors because they are small and flexible molecules. Boron complexes play a key role in boron neutron capture therapy. This radiotherapy is important in the treatment of melanoma, glioblastoma multiforme and other types of cancer. Boron complexes with ascorbic acid and glucose were prepared in this thesis and then characterized by high-resolution mass spectrometry (HRMS). Synthesised complexes were studied using collision-induced dissociation (CID), which led to the clarification of their fragmentation mechanism. Key Words Boron complexes, ascorbic acid, glucose, carbohydrates, mass spectrometry, electrospray ionization, ESI-MS, collision-induced dissociation
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Synthesis and Characterization of Arylspiroborates
Sedláčková, Simona ; Jelínek, Ivan (advisor) ; Sobotníková, Jana (referee)
Arylspiroborates have some very interesting properties, which include biological activities and the potential anti-tumor activities. The aim of the thesis was to prepare some complexes using mainly phenolic ligands (catchol, pyrogallol, 3-methoxycatechol, 2,3-dihydroxynaphthalene and 4tertButylcatechol) and their detailed characterization using ESI-QqTOF. With some of these prepared complexes collision experiments were performed and based on the results, the fragmentation mechanisms for these substances were proposed.
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